eFFECTOR Therapeutics is a clinical-stage biopharmaceutical company focused on pioneering the discovery and development of a new class of oncology drugs known as selective translation regulators (STRs). Translation is the process in cells whereby information in genetic sequences is used to direct synthesis of proteins. Each of eFFECTOR’s product candidates is designed to act on a single protein that regulates, in a coordinated manner, the expression of multiple functionally related proteins that together drive important biological processes such as immune evasion, stress and inflammatory responses.

In cancer, the tightly controlled translation of specific proteins becomes dysregulated, leading to malignancy characterized by uncontrolled growth, immune evasion and metastases. eFFECTOR believes that its therapeutic approach can restore the translational control of processes which tumors have hijacked for their benefit, while preserving normal cell function.

Translationally regulated processes can occur in tumor cells and non-tumor cells and are important for the survival and growth of tumors. By acting in immune cells, tumor cells or both, our product candidates have the potential to combine the benefits of multiple immunotherapies and/or targeted therapies in a single therapeutic agent. Our novel approach of acting on one protein to impact production of other proteins may enable us to successfully modulate therapeutically important oncology targets for which inhibitors have been historically difficult to discover.

eFFECTOR was founded in 2012 based on pioneering research in the laboratories of Drs. Davide Ruggero and Kevan Shokat and subsequently licensed proprietary applications of translational profiling technology from the University of California, San Francisco. The company’s scientific founders and management team comprise industry veterans who have played important roles in the discovery and development of marketed small molecule drugs and monoclonal antibody therapeutics in oncology and other disease areas.