eFFECTOR is pioneering the field of Selective Translation Regulators (STRs)
Transcription is the copying of DNA sequences into mRNA, whereas translation is the subsequent utilization of mRNA sequences to direct protein synthesis. While the regulation of transcription is widely recognized, eFFECTOR is pioneering the field of Selective Translation Regulators (STRs).











DNA
mRNA
Proteins
Regulation of transcription
Transcription
eFFECTOR Proteins
- Growth
- Immune Activity
- Inflammation
- Stress Response
Regulation of translation
Translation
Unregulated
routine/majority
Regulated
potent/minority
"Housekeeping"
Proteins

eFFECTOR’s translation regulation targets are downstream of key signaling pathways and impact multiple complementary cancer growth and survival mechanisms.
The importance of translation regulation in disease is becoming increasingly recognized in the pharmaceutical industry, and we believe we are at the forefront of discovering novel approaches to cancer therapy focused on STRs. Utilizing our proprietary selective translation regulation technology platform, we have developed an understanding of genes that are translationally dysregulated in multiple tumor types and other diseases. This has enabled us to identify specific points of therapeutic intervention that may have a meaningful clinical effect.



Immune
Resistance
Tumor
Metabolism
Inflammation
Tumor
Promotion
Sustaining
Proliferation
Resisting
Cell Death
MNK
eIF4E
Signaling
Inputs
Translational
Regulation
PI3K
RAS
MYD88
Cancer
Drivers














Our programs target three distinct subunits of the translation initiation complex: MNK 1/2, eIF4A and eIF4E. Each of these subunits regulates distinct sets of cancer genes.
- Key regulation points for potent biological processes
- Downstream from multiple oncogenes
- Upstream from key cancer driving processes
- Terminal node in key signaling pathways limits resistance mechanisms

Each target regulates a distinct cancer gene set
eFFECTOR Therapeutics
11120 Roselle Street, Suite A
San Diego, CA 92121
858-925-8215
info@effector.com