Enrollment in the Phase 2 portion of this study is open.
Non-germinal center B cell diffuse large B cell lymphoma (Non-GCB DLBCL), including Activated B cell (ABC) DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and is often classified as germinal-center B cell (GCB) or non-GCB, based on the pattern of gene expression in their tumors. The non-GCB group primarily includes activated B cell (ABC), but also includes other less common tumor types.
eFFECTOR is recruiting patients with ABC and other non-GCB DLBCL patients into its trial.
Activated B-cell (ABC) DLBCL – Derived from B cells that are in the process of differentiating from germinal center B cells to plasma cells. ABC patients have been found to have poorer outcomes than patients with GCB. ABC DLBCL represents the majority of non-GCB DLBCL.
Other Non-GCB DLBCL – In addition to ABC DLBCL, eFFECTOR is enrolling patients with DLBCL that are not otherwise classified as GCB. GCB DLBCL has a gene expression profile that is characteristic of B cells of the germinal center of the lymph node.